On November 24, 2025, President Donald J. Trump signed an executive order launching the "Genesis Mission," a national initiative to use artificial intelligence (AI) for accelerating scientific discovery. The order charges the Secretary of Energy with leading the effort, leveraging the National Laboratories to integrate powerful supercomputers and vast data sets into a unified, closed-loop AI experimentation platform.
This platform is designed to generate scientific foundation models and power automated robotic laboratories. The initiative will be coordinated by the Assistant to the President for Science and Technology, who will work with federal agencies, academia, and the private sector. The mission will focus on tackling grand challenges in priority fields including biotechnology, nuclear fusion energy, space exploration, quantum information science, and semiconductor development.
According to a White house press release, the administration's goal is to reverse a perceived decline in scientific productivity despite increased funding. By applying AI to model complex systems like protein structures and new materials, research that once took years could be condensed to weeks or months. The Genesis Mission is framed as a critical step to strengthen US economic competitiveness and national security by maintaining a dominant global position in AI and its scientific applications.
This federal push is backed by significant investment. According to the White House's FY2025 Budget, the National AI Initiative includes a request for $2.6 billion for non-defense AI research and development across the federal government. Furthermore, the CHIPS and Science Act provides a foundational investment, with the National Institute of Standards and Technology (NIST) allocated $1.8 billion in 2025, a portion of which is dedicated to AI research and its associated standards. This multi-billion dollar commitment underscores the administration's strategy to build the necessary infrastructure and talent to maintain a competitive edge.